|
Alcohol abuse
|
0.720 |
AlteredExpression
|
disease |
BEFREE |
Therefore, decreased function of CREB in the central nucleus of the amygdala might regulate anxiety and alcohol intake via decreased expression of NPY, and might provide a common link between anxiety and alcohol abuse disorders.
|
12967770 |
2003 |
|
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Somatostatin (SOM) and Neuropeptide Y (NPY) are two neuropeptides which are expressed in GABAergic interneurons with different fates in AD the former only being markedly affected.
|
30327597 |
2018 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript.
|
23697793 |
2013 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression.
|
30504424 |
2019 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY.
|
28582442 |
2017 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Human studies of central NPY levels in depression have, however, been inconclusive.
|
14757324 |
2004 |
|
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025).
|
30213237 |
2018 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
At t<sub>1</sub>, increased mean levels of NPY in CSF significantly correlated with impaired performance in most ISR scores (ISR total p = .018, depression p = .035, anxiety p = .008, nutrition disorder p = .047, supplementary items p = .038) and in several psychological SF-36 items (vitality p = .019, general mental health p = .001, mental component summary p = .025).
|
30213237 |
2018 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that changes of plasma levels of anti-NPY autoAbs are relevant to altered mood, while changes of their affinity may participate in altered appetite and body weight in patients with depressive disorder.
|
22365482 |
2012 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical specimens from patients with prostate cancer with higher score of depression revealed higher CD68<sup>+</sup> TAM infiltration and stronger NPY and IL6 expression.
|
30504424 |
2019 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the behavioral indicators of depression showed strong correlations with the serum levels and the hippocampal content of NPY.
|
28582442 |
2017 |
|
Depressive disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript.
|
23697793 |
2013 |
|
Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
EA treatment at CV12 reduced the levels of plasma monoamine neurotransmitters 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, dopamine, and norepinephrine; as well as stimulated the expression of GHRL and NPY to alleviate cisplatin-induced anorexia in rats.
|
31635295 |
2019 |
|
Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
We selected three human cancer cell lines [human melanoma (SEKI), human melanoma (G361), and human neuroepithelioma (NAGAI)] that have an ability to develop cancer cachexia syndrome with and without accompanying anorexia and examined the hypothalamic levels of mRNAs for neuropeptide Y (NPY), melanin-concentrating hormone, and orexin.
|
12094613 |
2001 |
|
Anorexia
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Leptin treatment decreases Arc ceramide levels, with the decrease being important in leptin-induced anorectic actions and down-regulations of NPY and Bsx.
|
21593415 |
2011 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, genetic mouse models in combination with novel neuron-controlling chemogenetic and optogenetic technologies have also uncovered additional functions for this Arc NPY population that go beyond the simple food intake stimulatory action and link these NPY neurons to the control of energy expenditure, thermogenesis, physical activity, food-seeking behavior, and anxiety.
|
31089694 |
2019 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
There is extensive evidence, from both clinical cases and rodent models, for reduced levels of the widely expressed neuropeptide Y (NPY) in anxiety and depressive disorders.
|
19264362 |
2009 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, alterations in anxiety- and depression-regulating genes were present in the hypothalamus of BACHD mice including reduced mRNA expression of neuropeptide Y, tachykinin receptor 3 and vesicular monoamine transporter type 2 as well as increased expression of cocaine and amphetamine regulated transcript.
|
23697793 |
2013 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Here we show that the claims of Zhou et al. that neuropeptide Y (NPY) diplotype-predicted expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting of phenotypically extreme individuals drawn from a large (n = 88,142) non-clinical population.
|
19340021 |
2009 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Decrease in NPY and PV expression in the hippocampus may explain the possible mechanism of hyperandrogenization induced anxiety.
|
31281833 |
2019 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It is suggested that NPY may influence ethanol consumption by regulating basal levels of anxiety, by modulating the sedative effects of ethanol, and/or by modulating ethanol's rewarding properties.
|
15337375 |
2004 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased melanocortin and decreased neuropeptide Y activity due to changes in histone acetylation in emotional brain circuitry may play a role in adolescent intermittent ethanol-induced anxiety phenotypes in adulthood.
|
28575455 |
2017 |
|
Anxiety Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A recent study found NPY expression to be inversely correlated with trait anxiety.
|
20037921 |
2010 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hippocampal neuropeptide Y protein expression following controlled cortical impact and posttraumatic epilepsy.
|
30146352 |
2018 |
|
Epilepsy
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to compare insulin, leptin, neuropeptide Y and ghrelin levels in children with epilepsy receiving monotherapy with topiramate (TPM) and valproic acid (VPA), the drugs whose effects on body weight have been most discussed, with those of a control group.
|
29679911 |
2018 |